Warmest cheers!

Cutting-Edge Methods of Peyronie’s Disease Treatment: Stem Cells, PRP, ESWT

Looking for a method to treat Peyronie’s disease and restore a healthy sexual life? You are at the right place. Let’s see what PD is, what harm it brings, and why it should be cured as soon as possible after the diagnosis is established.

Peyronie’s disease (PD) is a condition caused by fibrous scar tissue that occurs inside the penis and results in painful erections and the inability to engage in sexual activity. The scarring forms the plaques within the penis and promotes unusual penile curvature which is observed only when the penis is erect.

Although each penis varies in shape and size, having a curved erection can bring hurtful discomfort, result in complete inability to have sex, cause partial erectile dysfunction and even result in depressive disorders brought by stress and anxiety.

PD is a condition that rarely goes away on its own, especially when the plaques are palpable enough to put a diagnosis and there is a risk of plaques being calcified.

We’re revealing the causes, phases, symptoms, diagnostics, and treatment currently available for this intricate disorder.

Causes of Peyronie’s Disease

Modern medical experts can just suppose what causes Peyronie’s disease since there is no explicit conclusion concerning the true reasons for it. Some of the possible causes of PD are as follows:

  • penile trauma that results in fibrosis;
  • injury to the fibrous envelope of the penis;
  • aging and genetics;
  • erectile dysfunction;
  • prostate cancer.

Some men are just more exposed to the formation of plaques inside the penis that result in PD than others. However, not every penile curvature should be considered to be Peyronie’s disease. Let’s unveil some more symptoms of the disorder in detail.

Symptoms of PD

Except for the main mentioned symptom of Peyronie’s disease which is the penile curvature and palpable plaques inside the penis which prevent from having sex and cause pain when the penis is erect, here are some other symptoms that can also signal that the disorder exists:

  • A significant unnatural bend to the penis. This bend can curve downwards, upwards, or to one of the sides.
  • Instable erections. The disorder can cause issues with erectile function and make your erections not firm enough or irregular.
  • Penile shortening. The curvature can cause the penis to shorten and change in size.
  • Painful erections. This symptom is one of the main marks of PD.
  • Other penile deformations. In some cases of Peyronie’s, the erect penis may have narrowings, an hourglass-like look, or even pinchers.

The PD is diagnosed pretty easily as the symptoms are perceived and observed both by experts and a patient himself.

Diagnostics and Phases

To detect Peyronie’s disease a doctor makes the following:

Physical examination. A doctor should palpate the penis when it’s not erect to locate the scar tissue and determine its volume and amount. A doctor might also ask a patient to show the photos of the erect penis to see how much it is bent and observe the type of curvature.

Other diagnostics. A doctor might suggest an ultrasound to examine the erect penis for the availability of plaques. A special injection is administered into the penile tissue to cause the erection and properly start the diagnostics.

The treatment of Peyronie’s disease is selected based on the phase of the condition. The PD can occur and worsen with time, so experts distinguish its two phases:

Acute: The acute phase is the early stage of the disorder. It supposes that you perceive the pain in the penis; admit its deformity and curvature and this causes some discomfort. This phase can last from 2 weeks up to several years.

Chronic: The chronic phase is characterized by stable symptoms. However, you don’t experience any penile pain anymore. The curvature is already formed and the shortening or deformity of the penis has become permanent. Such phase starts in a year or more after the first symptoms have occurred.

Treatment of Peyronie’s Disease

For the acute phase some of the following standard treatments are usually recommended:

Penile traction. In this case, the specific traction device is fixed on the penis and worn for a certain period of time to make it straighten.
Injections. Sometimes a doctor prescribes medical injections optionally.
Medication. A doctor may also recommend taking FDA-approved medications like collagenase, verapamil, or interferon.

For the chronic phase, doctors typically recommend surgery or watchful waiting.

In case of surgery recommended. Some patients prefer to monitor the condition of their penile tissue to learn if it stays unchangeable, improves, or worsens. Depending on the results of watching, a patient can resolve whether to turn to surgery or refuse it.

Methods that we offer to our patients who want to treat their Peyronie’s disease are PRP, stem cells, and shock wave therapy.

Stem Cells and PRP for Peyronie’s Disease

Stem cells are advanced methods of treatment mostly used for overcoming the consequences of osteoarthritis and widely applied in regenerative medicine for anti-aging purposes. Please be sure to read more of stem cell therapy here to learn more specific details on how the therapy is provided and what currently recognized results are already obtained.

The peculiarity of stem cells is that by origin they are raw body’s materials and are able to transform into the cells of different organs and tissues. As the stem cells are divided (this is called the process of differentiation), they produce a number of growth factors and other compounds that promote the repair of tissue if it has been damaged.

Stems cells differentiation is bound to the immune response which reduces inflammation and eliminates autoimmune conditions that usually appear due to the over-active immune response.

In the case of PD treatment, the relevant compounds secreted by the stem cells during their differentiation reduce the release of structural proteins that form the fibrous plaques inside the penis.

In 2010, scientists investigated the use of stem cells for the treatment of Peyronie’s disease and revealed that they prevent the progression of the disorder in the chronic phase.

Stem cells that we use for the PD treatment are usually autologous ones which means they are taken from the patient’s own tissues, and then processed and cleared to be reinjected into the damaged area on the body. Such therapy is often combined with platelet-rich plasma (PRP) treatment.

Please go here to read more about PRP-based treatment to learn how the plasma is obtained and injected into the target tissues to promote healing and restoration.

Briefly, platelet-rich plasma is obtained from a patient’s sample of blood which is centrifuged in a vial to be separated into layers. Platelets and growth factors contained in PRP evoke healing abilities of the body itself and repair the damaged tissues.

In 2017 there was a study conducted by scientists to investigate the use of platelet-rich plasma for the PD treatment. The experiment was supposed providing of 5 procedures over a period of 2 months and then analyze the changes in penile curvature and the size of plaques inside the penis that prevented normal sexual function.

After each patient received 5 injections during a mentioned period, the investigators admitted the improvement of the curvature as well as reported the reduction in the size of penile plaques. By the way, the erectile function of patients had also been improved and they reported better ability for sexual intercourse.

Shock Waves for Peyronie’s Disease

Extracorporeal shock wave therapy also known as LiESWT is also used by our medical experts for the treatment of PD. Please be sure to click here to learn more about the therapy itself and discover how it is typically provided.

Since May 15, 2002, shock treatment has been commonly used to blast the stones in kidneys and break other calcium deposits in organs to crush them into pieces and help them naturally eliminate out of the body.

In the treatment of PD, low-intensity acoustic waves are delivered to the penile tissue with a wand-like device to reach the plaques and soften them as much as possible to straighten the penis when it is erect.

In the study conducted at the Hôpital Foch in Suresnes, France, 54 men with Peyronie’s disease were involved in the investigation to test the effect of ESWT therapy on breaking the plaques and reducing the curvature.

Out of 35 patients that used to have pain during erection, 91% admitted the relief after the continuous treatment with ESWT. 54% (29 patients) that had been suffering from unnatural curvature admitted a significant improvement of the penile angle, and 25 of them reported the smoothing of penile plaques. In total, 61% of patients admitted they had essential improvement of their condition after the therapy.

For now, you can feel free to contact a team of our medical experts to discover more replies to your possible questions that might have occurred. Schedule a free consultation here.