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PDE5 Inhibitors to Promote Regular Spontaneous Erections

Are you looking for a way to cure your erectile dysfunction? PDE5 (Phosphodiesterase 5) inhibitors like Viagra, Cialis, Levitra, and Stendra are recognized to be the classic method of treating vasculogenic ED that has occurred because of the poor blood flow to the penis.

PDE5 is an enzyme that regulates cGMP-specific signaling pathways in physiological processes like contraction and relaxation of smooth muscles. In some foods, like Thai black ginger, PDE5 inhibitors are present in a natural form and can affect the blood flow in the body as well as influence the way of communication between cells.

When the level of cGMP in tissues is lowered, this causes pathological conditions that badly influence muscle relaxation, and the inhibition of the enzyme can alter this disorder. This is why PDE5 inhibitor is typically the main component of pills for ED treatment.

When erectile dysfunction is a permanent condition that bothers you pretty often, it’s time to consider taking pills. Let’s see what Phosphodiesterase 5-based pills are, learn their benefits and precautions for using them further.

What are PDE5 inhibitors for ED?

Pills containing PDE5 inhibitors are used to treat vasculogenic erectile dysfunction or pulmonary hypertension. If in people with pulmonary hypertension such inhibitors work to increase the blood flow in the lungs and lower blood pressure, then in men with ED the same component can improve erectile function.

Taking pills for restoring erectile function doesn’t mean that erections will occur by themselves or last for all time since you will nevertheless have to be sexually aroused to get the erection. You can take PDE5 enzyme inhibitors in the form of pills that are available under the brand names:

  • avanafil (Stendra);
  • vardenafil (Levitra);
  • tadalafil (Cialis, Adcirca);
  • sildenafil (Viagra, Revatio).

We will create a small breakdown of every medication to give you an insight into the details of each one:


Sildenafil is available under the Viagra brand name and is available for treating erectile dysfunction and high blood pressure. This type of drug comes in dosages of 25 milligrams, 50 mg, and 100 mg. The peculiarities of Sildenafil are as follows:

  • This is a fast-acting drug since it starts to take effect about 30 minutes after taking.
  • It is a widely recognized medicine with well-established efficacy confirmed by multiple clinical trials.
  • The effect of Viagra can last up to 4 hours without any risk for the penile tissue.

Side effects are typically slight and they can include allergic reactions and issues with blood pressure. If a man has heart disorders they are not recommended to take sildenafil. Men with chronic diseases such as multiple sclerosis should also abstain from taking this medication.


Tadalafil is known and sold in pharmacies as Cialis and is used both for ED treatment, treating high blood pressure in the lungs, and prostate enlargement. For ED treatment, it is usually taken in the form of oral pills. Some of the advantages of Cialis include:

  • The drug can stay in the body for up to 36 hours, in rare cases, it can last up to 72 hours, so the erection will be able to appear spontaneously as in your younger age or at any time when you are about to have sex.
  • This drug is effective even if you take 2.5 mg – 5 mg once a day.
  • A daily pill can help engage in daily sexual activity without trouble.

Among the disadvantages of tadalafil, one can distinguish a comparatively high price of the drug if it is taken on a daily basis. In addition, we should say the pill only triggers the erection in response to sexual stimulation but doesn’t treat the underlying cause of erectile dysfunction.


Avanafil is available for sale as Stendra and, unlike sildenafil and tadalafil, it is not offered in generic form. The drug’s effect takes place by increasing the blood flow to the penile tissue. The benefits of Stendra are as follows:

  • It starts to work in 15 minutes after the drug is taken.
  • Multiple pieces of research have proven the effectiveness and safety of avanafil.
  • The medicine can stay in the body and take action for up to 6 hours.

The effect of Stendra is quick to occur but in comparison with other similar pills, it is also pretty quick to disappear. As the drug is not available in the generic form it can be pretty expensive.


Vardenafil is widely known as Levitra and it also works by boosting the flow of blood to the penis. The advantages of Levitra are obvious:

  • It is a clinically proven medicine for treating erectile dysfunction.
  • The initial dosage of vardenafil should be 5 mg a day and then you can take 10 mg without any risk.
  • The price of Levitra generic is much lower in comparison with similar pills.

The disadvantage of medication includes a comparatively long period before taking the effect (up to 1 hour after taking the pill).

For any other questions concerning precautions, personal dosage, diagnostics to determine the cause of your ED, and more related inquiries, please schedule a free consultation here.